Biology and pharmacology of the effects of alcohol at different doses.

Individual (genetic) variations in responses to alcohol and drugs.

Efficacy of mandated vs. voluntary treatment for alcoholism and drug dependence.

The psychological and physiological basis of prevention strategies.

Factors influencing the risk for future alcohol and drug dependence.

Limits on diagnostic accuracy of tests for alcohol and drugs of abuse.

Pharmacological interventions for treatment of drug dependence.

Is drug dependence a disease?: models of addiction þ